News - Part 193

Encore Discussion about Dravet Syndrome

Voices & Viewpoints Discusses Dravet Syndrome Picking up from where they left off in their last radio discussion Harriet Davies and Isaac Winter discuss Dravet Syndrome.  A severe form of epilepsy that typically manifests after the first six months of life and before the child’s first birthday.  This disease is considered a rare disease, and […]

Understanding Dravet Syndrome

The Dravet syndrome Spectrum Introduction Sodium channel related seizure disorders encompass a spectrum that ranges from simple febrile seizures (FS) and genetic epilepsy with febrile seizures plus (GEFS+) at the mild end to Dravet syndrome (Ds) at the severe end. There are currently 359 SCN1A disease-causing mutations reported in the literature. Recent discovery of the […]

Stiripentol and Anesthesia

Q:  My daughter is having surgery.  What type of anesthesia can be used with stiripentol?  Are there interactions between stiripentol and anesthesia?  I called Biocodex, the maker of stiripentol, and they didn’t have the answer. A:    Pharmaceutical companies don’t generally give information out on questions that have not been studied or documented with literature. Most […]

James Hopkins, PharmD

ICE the Inferno As many as 40% of children with epilepsy do not find seizure freedom with anti-epileptic drug therapy and are considered “refractory” , “intractable“, or “drug resistant” patients. An astounding 70% of patients suffering from epilepsy do not know what is causing their seizures, and the cause is determined as “idiopathic” or “cryptogenic” . The definition of “drug resistant” epilepsy as failure of adequate […]