Dilantin (Phenytoin) is an anticonvulsant or antiepileptic drug used to treat epilepsy, depression, and anxiety. The drug decreases nerve impulses that cause seizures. However, this medication does not cure epilepsy but only controls seizures.
How to buy Dilantin?
If you want to buy cheap Dilantin, pay attention that the above mention price in the lowest one you can find on the net. Order the generic version of the medication if you want to save money and get the same medicinal effect and drug quality. The ordering process will take about 5 minutes and you can expect your order to be delivered in a few days.
- Indications
- Dosage and instructions for use
- Overdose
- Contraindications
- Side Effects
- Drug Interactions
- Special Precautions
- Storage
Product info
Indications
- Epilepsy (large convulsive seizures); epileptic status with tonic-clonic seizures; epileptic seizures in neurosurgery (prevention and treatment);
- Ventricular arrhythmias (including with glycosidic intoxication or associated with intoxication with tricyclic antidepressants);
- Neuralgia of the trigeminal nerve (as a second-line agent or in combination with carbamazepine).
Dosage and instructions for use
The drug is taken orally.
For adults, the initial dose is 3-4 mg/kg/day, followed by increasing the dose to achieve the optimal therapeutic effect. In most cases, the maintenance dose is 200-500 mg/day in one or more doses.
For children – 5 mg/kg/day in two doses, followed by a dose increase of not more than 300 mg/day.
Supportive doses – 4-8 mg / kg / day.
For IV introduction to adults and children, the initial dose is 15-20 mg/kg. Depending on the clinical situation, a single dose can be 50-100 mg/kg. For newborns, the initial dose is also 15-20 mg/kg.
Adults can be administered in a single dose of 100-300 mg.
Overdose
Symptoms of overdose with phenytoin may include:
- uncontrolled eye movement;
- loss of coordination;
- slow or slurred speech;
- the uncontrolled concussion of body part;
- nausea;
- vomiting;
- difficulties in understanding reality;
- coma (loss of consciousness over a long period of time)
Patients with manifestations of intoxication (cerebellar symptoms, coma and respiratory depression) are treated according to generally accepted methods. The patient may remain unconscious for a long time since the drug is excreted in accordance with the kinetics of zero order but it will be restored if breathing and circulation are maintained.
Contraindications
You should not use generic Dilantin if you are allergic to phenytoin or similar medications if you have:
- a history of liver problems caused by phenytoin;
- the condition of the heart called the “AV block” of the 2nd or 3rd degree;
- the history of slow heartbeats that caused you to faint;
- the condition for which you take Delavirdine (Rescriptor).
To ensure that Dilantin is safe for you, tell your doctor if you have:
- liver disease;
- the history of abnormal heart rhythm detected on the ECG (electrocardiograph);
- diabetes;
- a history of depression;
- a history of suicidal thoughts or actions;
- vitamin D deficiency or any other condition that causes thinning of the bones;
- porphyria (a genetic disorder of an enzyme that causes symptoms affecting the skin or nervous system);
- if you drink a lot of alcohol.
Side Effects
Dilantin can cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- increased blood sugar;
- difficulty falling asleep or sleeping;
- uncontrolled eye movement;
- abnormal body movements;
- loss of coordination;
- confusion;
- slowing of thinking;
- slurred speech;
- dizziness;
- headache;
- nausea;
- vomiting;
- constipation;
- unwanted hair growth;
- coarse facial features;
- lip extension;
- gum proliferation;
- pain or curvature of the penis
Some side effects can be severe. If you experience any of the following symptoms, consult your doctor:
- swollen glands;
- fever;
- blisters;
- rash;
- pain in the joints;
- yellowing of the skin or eyes;
- pain in the right upper abdomen;
- excessive fatigue;
- unusual bruising or bleeding;
- loss of appetite;
- influenza-like symptoms
Dilantin can cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication
Drug Interactions
- Alcohol and other drugs that depress the central nervous system – increased oppression. In chronic alcoholism, the concentration and effectiveness of phenytoin decrease; with simultaneous single administration of phenytoin and alcohol – an increase in the concentration of phenytoin;
- Amiodarone, anticoagulants (coumarinic or indanedione), disulfiram, isoniazid, itraconazole, ketoconazole, miconazole, omeprazole, ranitidine, sulfonamides, phenylbutazone, chloramphenicol, cimetidine, fluconazole, fluoxetine – an increase in the concentration and toxicity of phenytoin;
- Valproic acid – inhibition of the metabolism of phenytoin, an increased risk of developing hepatic toxicity of valproic acid, a decrease in its concentration. Monitoring of drug concentrations is necessary;
- Glucocorticoids, estrogen-containing contraceptives, estrogens, theophylline and other xanthines, vitamin D – a decrease in their concentration and efficiency due to increased metabolism;
- Carbamazepine and phenobarbital enhance the elimination of phenytoin;
- Lamotrigine – a decrease in efficiency due to the induction of metabolism;
- Lidocaine, β-adrenoblockers – increased cardiodepressive effect;
- Paracetamol – an increase in hepatotoxicity;
- Rifampicin – a decrease in the effectiveness of generic Dilantin due to the induction of metabolism.
Special Precautions
- Do not use this medication during pregnancy, except when the benefit of treatment for the mother exceeds the risk to the fetus. There are separate data on the formation of tumors (including neuroblastoma), splitting of the upper lip and palate in children whose mothers received Dilantin during pregnancy;
- Phenytoin is excreted in breast milk in concentrations sufficient to cause side effects in the infant. In this regard, the use of phenytoin during lactation is not recommended;
- A sudden cessation of phenytoin treatment in patients with epilepsy can provoke the development of withdrawal syndrome;
- In patients with epilepsy, if an abrupt withdrawal of phenytoin is necessary (for example, with the development of allergic reactions or hypersensitivity reactions) anticonvulsants other than hydantoin derivatives should be used;
- Phenytoin undergoes intensive metabolism in the liver, so patients with impaired liver function, as well as the elderly, require a correction of the dosing regimen;
- During the treatment, especially long, a diet that satisfies the need for vitamin D is recommended, exposure to UV radiation;
- When using the drug in children during growth, the risk of side effects from the connective tissue increases;
- In acute alcohol intoxication, the concentration of phenytoin in the plasma can increase, with chronic alcoholism, it decreases;
- Influence on the ability to drive vehicles and control mechanisms: during treatment, the speed of psychomotor reactions slows down. This should be taken into account by persons engaged in potentially hazardous activities requiring increased attention and speed of psychomotor reactions.
Storage
Store the packaging in a dry place protected from light, out of reach of children, at a temperature of 41 to 86 ° F.